4-Desoxy-thiazolo[5,4-c]rifamycin derivatives and their use as a

Details 4-Desoxy-thiazolo[5,4-c]rifamycin derivatives and their use as a 4-Desoxy-thiazolo[5,4-c]rifamycin derivatives and their use as a

1979-03-19

1980-07-15

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2602393P, C07D51520, A61K 31425

Patent

active

042128730

ABSTRACT:
Novel 4-desoxy-thiazolo[5,4-c]rifamycin derivatives of formula I ##STR1## wherein R stands for a group --OR.sub.1, --NR.sub.2 R.sub.3 or --NHCOR.sub.4 wherein R.sub.1 represents alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl, R.sub.2 and R.sub.3 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl or R.sub.2 and R.sub.3 taken together with the adjacent nitrogen atom may represent a 5 to 7 membered heterocyclic ring and R.sub.4 is a radical selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl; R.sub.5 is hydrogen or acetyl; and a process for preparing them.
The novel compounds have an antibacterial utility.

REFERENCES:
patent: 4042683 (1977-08-01), White et al.
patent: 4116957 (1978-09-01), Rossetti et al.
patent: 4129562 (1978-12-01), Cricchio
patent: 4144234 (1979-03-01), Cricchio

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