4-desoxy-4-epipodophyllotoxin derivative or pharmaceutically acc

Details 4-desoxy-4-epipodophyllotoxin derivative or pharmaceutically acc 4-desoxy-4-epipodophyllotoxin derivative or pharmaceutically acc

1995-06-06

1996-11-05

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544375, 546187, 546197, 546 14, 5462837, 548526, 549298, C07D41300, C07D40700

Patent

active

055719147

ABSTRACT:
A 4-desoxy-4-epipodophyllotoxin derivative of the following formula ##STR1## wherein R and R.sub.1 are as defined in the specification or a pharmaceutically acceptable salt thereof as well as an antitumor composition comprising such derivative or salt as an active ingredient.

REFERENCES:
Podophyllotoxin Analogs: effects on DNA Topoisomerase II, Tubulin Polymerization, Human Tumor Kb Cells, and Their VP-16-Resistant Varients (1989).
Chemical Abstracts, vol. 112, No. 1, 1 Jan. 1990, JP-A-1 117 885.
Chemical Abstracts, Vo. 115, No. 19, 11 Nov. 1991, JP-A-3 127 792.

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