4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use

Details 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use

1987-08-20

1989-09-19

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 172, 536 182, 536 41, 514908, C07D 2100, C07H 1524

Patent

active

048682918

ABSTRACT:
Novel 4'-deshydroxyepipodophyllotoxin glucosides are provided as antitumor agents useful in inhibiting the growth of mammalian tumors. The invention also provides novel intermediates and processes for the preparation of the 4'-deshydroxyepipodophyllotoxin glucoside end-products. A preferred embodiment is 4'-deshydroxyetoposide.

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J. Electroanal. Chem., 184: 317-329 (1985); Holthuis et al.
Biochemistry, 23: 1183-1188 (1984); Long et al.

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