4 Deoxy-4-methylene oleandomycin and derivatives thereof

Details 4 Deoxy-4-methylene oleandomycin and derivatives thereof 4 Deoxy-4-methylene oleandomycin and derivatives thereof

1981-04-20

1982-06-22

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 73, 536 74, C07H 1708, A01N 900

Patent

active

043363687

ABSTRACT:
Derivatives of oleandomycin, its 11-trimethylsilyl ether and 11-trimethylsilyl-2'-alkanoyl esters and processes for preparation thereof wherein the L-oleandrosyl moiety is modified at the 4"-position to provide derivatives thereof wherein said moiety has formula ##STR1## wherein A and B when taken together are .dbd.CHX wherein X is H, --CN, --COOR.sub.3, --SR.sub.3 ', --S(O)R.sub.3 ', --S(O).sub.2 R.sub.3 ' or ##STR2## A when taken individually is hydrogen; B when taken individually is --CHO or --CH.sub.2 Z wherein Z is hydrogen, --OR.sub.3, --COOR.sub.3, --SR.sub.3 ', --S(O)R.sub.3 ', --S(O).sub.2 R.sub.3 ', --CN or --(CH.sub.2).sub.n --NR.sub.5 R.sub.6 ;

REFERENCES:
patent: 4085119 (1978-04-01), Myers
patent: 4090017 (1978-05-01), Sciavolino
patent: 4124755 (1978-11-01), Bright

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