4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical

Details 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical

1984-05-10

1985-08-27

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

260365, 536 64, A61K 3170, C07H 1524

Patent

active

045378827

ABSTRACT:
Compounds of the formula (I), acid addition salts thereof, and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is hydroxy; one of X and X' is hydrogen and the other is a halogen atom selected from the group consisting of fluorine, chlorine, bromine, and iodine; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and --OCOR; one of Z and Z' is hydrogen and the other is hydrogen, hydroxy or --OCOR; and R is a lower alkyl group.

REFERENCES:
patent: 4046878 (1977-09-01), Patelli et al.
patent: 4058519 (1977-11-01), Arcamone et al.
patent: 4166848 (1979-09-01), Bernardi et al.
patent: 4201773 (1980-05-01), Horton et al.
patent: 4345070 (1982-08-01), Suarato et al.
patent: 4427664 (1984-01-01), Horton et al.

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