4-dedimethylaminotetracycline derivatives

Details 4-dedimethylaminotetracycline derivatives 4-dedimethylaminotetracycline derivatives

2005-01-05

2008-11-25

Badio, Barbara P (Department: 1612)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

C514S825000, C514S866000, C514S903000

Reexamination Certificate

active

07456158

ABSTRACT:
The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.

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