4-cyanopyrazole-3-carboxamide derivatives, preparation, and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S364100, C548S377100, C548S357100, C514S359000

Reexamination Certificate

active

11315774

ABSTRACT:
The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I):in which R1, R2, R3, R4, R5, R6, R7, R8are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).

REFERENCES:
patent: 6028084 (2000-02-01), Barth et al.
patent: 6344474 (2002-02-01), Maruani et al.
Meschler et al. Biochemical Pharmacology, (2000), 60, p. 1315-23.
Ahmad Sami Shawali, Synthesis and Tautomeric Structure of some 2H-Pyrazolo [3,4-d] pyridazines, J. Heterocyclic Chem. (1977, pp. 375-381, vol. 14, No. 3).
Justin P. Meschler et al., Inverse Agonist Properties of -(Piperidin-1-yl)-5-(4-chlorophenyl) -1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCI (SR141716A) and -(2-Chlorophenyl) -4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic Acid Phenylamide (CP-272871) for the CB1 Cannabinoid Receptor, Biochemical Pharmacology (2000, pp. 1315-1323, vol. 60, No. 9).
1H-Pyrazole-3-carboxylic acid, 1-(4-bromophenyl)-4-cyano-5-(4-methoxyphenyl)-, ethyl ester, Chemical Abstract 2003:1939325, (Jul. 9, 2002).

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