4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S311400, C548S316400

Reexamination Certificate

active

11232383

ABSTRACT:
Compounds of Formula 1where the variables have the meaning defined in the specification are agonists of alpha2adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2Band/or alpha2Cadrenergic receptors in preference over alpha2Aadrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

REFERENCES:
patent: 4798843 (1989-01-01), Kruse
patent: 6124300 (2000-09-01), Rajagopalos et al.
patent: 6486187 (2002-11-01), Venet
patent: 0301603 (1989-02-01), None
patent: 0302603 (1989-02-01), None
patent: 1499485 (1979-02-01), None
patent: 6067368 (1994-03-01), None
patent: 2002097310 (2002-07-01), None
patent: 2002097312 (2002-07-01), None
patent: WO 99/28200 (1999-06-01), None
patent: WO 99/28300 (1999-06-01), None
patent: WO 01/00586 (2001-01-01), None
patent: WO 02/36162 (2002-05-01), None
patent: WO 03/099795 (2003-12-01), None
patent: WO2005/034849 (2005-04-01), None
patent: WO2005/034946 (2005-04-01), None
Trojanowski, John Q. “Alzheimer's Disease, Parkinson's Disease and Related Brain Disorders:Brief Overview for Patients and Caregivers,” internet article, Oct. 1999, found on http://pennhealth.com.
Ruffolo, Jr., “α-Adrenoreceptors”: Molecular Biology, Biochemistry and Pharmacology, (Progress in Basic and Clinical Pharmacology series, Karger, 1991).
Messier et al, High Throughput Assays of Cloned Adrenergic, Muscarinic, Neurokinin, and Neurotrophin Receptors in Living Mammalian Cells, 1995, 76, pp. 308-311.
Conklin et al, “Substitution of three amino acids switches receptor specificity of Gqα to that of G1α”, 1993, Nature 363: 274-6.
Dirig et al, “Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli”,J. Neurosci. Methods, 1997, 76: 183-191.
Hargreaves et al, “A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia”, 1988, Pain 32: 77-88.
Dixon, W.J., “Efficient Analysis of Experimental Observations”, Ann. Rev. Pharmacol. Toxicol., 1980, 20: 441-462.
Minami et al, “Allodynia evoked by intrathecal administration of prostaglandin E2to conscious mice”, 1994, 57 Pain, 217-223.

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