4-(cinnolinylamino or quinazolinylamino)benzenesulphonamides and

Details 4-(cinnolinylamino or quinazolinylamino)benzenesulphonamides and 4-(cinnolinylamino or quinazolinylamino)benzenesulphonamides and

1985-06-13

1987-02-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514259, 544235, 544293, 546232, 548566, A61K 31505, A61K 3150, C07D47102, C07D21114

Patent

active

046409203

ABSTRACT:
Novel quinazoline and cinnoline derivatives having the formula ##STR1## (wherein one of A and B is CH and the other one of A and B is N; X.sub.1 is halogen or CF.sub.3 and X.sub.3 is one of the groups II, III, IV or V ##STR2## where Q is lower alkylene; R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are independently lower alkyl or R.sub.2 and R.sub.3 are a divalent radical such that HNR.sub.2 R.sub.3 is a secondary cyclic amine with 5 to 7 ring atoms; R.sub.4 is lower alkyl; n is 0 or 1; the rings shown in formulae III and IV are piperidine or pyrrolidine optionally substituted by lower alkyl; and the ring shown in formula V is piperazine optionally substituted by lower alkyl) and their pharmaceutically acceptable salts are useful as pharmaceuticals particularly as anti-hypertensives. Novel intermediates are also described including the corresponding sulphonic acids of formula I (where A, B and X.sub.1 are defined above and X.sub.3 is OH).

REFERENCES:
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patent: 3933829 (1976-01-01), Archibald et al.
patent: 3954754 (1976-05-01), Schenker
patent: 4132786 (1979-01-01), Moreau et al.
patent: 4211776 (1980-07-01), Moreau et al.
patent: 4351940 (1982-09-01), Hess et al.
patent: 4396622 (1983-08-01), Jozic
Martin et al., J. Med. Chem., vol. 7, No. 6, pp. 812-814, (1964).
Botros et al., Chemical Abstracts, vol. 90: 54902x, (1979).

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