4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514312, 546159, 546153, A61K 3147, C07D21538, C07D21514

Patent

active

061470902

ABSTRACT:
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

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Gordon DJ, et al., Circulation. 79(1):8-15, Jan. 1989, "High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies".

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