4-Carboxy azetidinone compounds and production thereof from dike

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07D20508

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045565147

ABSTRACT:
.beta.-Lactam compounds which are useful as intermediates for the production of carbapenem or penem derivatives and a process for producing the same. The process comprises reacting a Schiff base with diketene in the presence of an imidazole, reducing the acetyl group of the resulting N-protected-3-acetyl-2-azetidinone-4-carboxylic acid ester, and removing the protecting group for a carboxyl group from the resulting 3-(1-hydroxyethyl)-2-azetidinone-4-carboxylic acid derivative.

REFERENCES:
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Neider et al., Tet. Letters 23, 2293, (1982).
Sankyo et al., Chem. Abs. 94, 103147y, (1980).
Sankyo et al., Chem. Abs. 96, 85334s, (1981).
Sankyo et al., Chem. Abs. 98, 72422k.
Hagemeyer et al., Chem. Abs. 43, 839e, (1949).
Kato et al., Chem. Pharm. Bull. 24, 356, (1976).

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