4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and thei

Details 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and thei 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and thei

1983-05-31

1986-02-25

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

514210, 260239A, 548195, C07D41712, A61K 31425, C07D20508, C07D27738

Patent

active

045728011

ABSTRACT:
Disclosed are compounds of the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group and R.sup.2 is a hydrogen atom or an ester residue, said derivative having the (3S,4S)-configuration; and pharmaceutically acceptable salts and esters thereof.
The compounds have antimicrobial and/or .beta.-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals.

REFERENCES:
patent: 4200572 (1980-04-01), Gleason et al.
patent: 4225586 (1980-09-01), Imada et al.
patent: 4229436 (1980-10-01), Imada et al.
patent: 4502994 (1985-03-01), Wei
Imada et al., Nature, vol. 289, pp. 590-591 (1981).
Sykes et al., Nature, vol. 291, pp. 489-491 (1981).
12th International Congress of Chemotherapy, Florence, Italy, Jul. 19-24, 1981, pp. 55-56.
Sykes et al., Journal of Antimicrobial Chemotherpy, (1981) 8 Suppl. E 1-16.
Sykes et al., Chemical Abstracts, 95, 217370S (1981).
Matsuo et al., Chemical Abstracts, 95, 97566M (1981).

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