4-Carbamoylimidazolium-5-olate derivatives

Details 4-Carbamoylimidazolium-5-olate derivatives 4-Carbamoylimidazolium-5-olate derivatives

1982-04-07

1984-08-07

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 173, C07H 1702, A61K 3170

Patent

active

044645317

ABSTRACT:
There are provided compounds of the formula: ##STR1## wherein either R.sub.1 or R.sub.2 is a hydrogen atom, a hydroxy group, an acyloxy group, a phthalimido group or an acetamido group and the other is a hydrogen atom; either R.sub.3 or R.sub.4 is a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R.sub.5 or R.sub.6 is a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R.sub.7 or R.sub.8 is a hydrogen atom, a methyl group, a hydroxymethyl group, an acyloxymethyl group, an alkoxycarbonyl group, a group of the formula: ##STR2## (wherein X.sub.1 and X.sub.2 are a hydrogen atom or a lower alkyl group), or a carboxyl group and the other is a hydrogen atom; either R.sub.11 or R.sub.12 is a hydrogen atom, a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R.sub.13 or R.sub.14 is a hydroxy group or an acyloxy group and the other is a hydrogen atom; either R.sub.15 or R.sub.16 is a methyl group, a hydroxymethyl group or an acyloxymethyl group and the other is a hydrogen atom; and a process for producing them. These compounds are useful as antitumor agents.

REFERENCES:
patent: 4140788 (1979-02-01), Atsumi et al.
patent: 4218457 (1980-08-01), Atsumi et al.
patent: 4248999 (1981-02-01), Baba et al.
patent: 4260774 (1981-04-01), Atsumi et al.
patent: 4317825 (1982-03-01), Atsumi et al.
patent: 4332806 (1982-06-01), Atsumi et al.
Tarumi et al., Reprint from The Journal of Heterocyclic Chemistry, 17, (1425-1433), 1980.

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