4-bromo or 4-iodo phenylamino benzhydroxamic acid...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C564S163000

Reexamination Certificate

active

11249543

ABSTRACT:
Phenylamino benzhydroxamic acid derivatives of the formulawhere R1, R2, R3, R4, R5, and R6are hydrogen or substituent groups such as alkyl, and where R7is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.

REFERENCES:
patent: 5155110 (1992-10-01), Connor et al.
patent: 5525625 (1996-06-01), Bridges et al.
patent: 5877190 (1999-03-01), Dhainaut et al.
patent: 6251943 (2001-06-01), Barrett et al.
patent: 0316630 (1989-05-01), None
patent: WO89/03818 (1989-05-01), None
patent: WO98/37881 (1998-09-01), None
Connor, D. et al., “Dual Inhibitors Of 5-Lipoxygenase And Cyclooxygenase,”Biological Inhibitors, 1996, Harwood Academic Publishers, Netherlands, 2, 47-86.

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