4 beta-amino podophyllotoxin analog compounds and methods

Details 4 beta-amino podophyllotoxin analog compounds and methods 4 beta-amino podophyllotoxin analog compounds and methods

1992-12-08

1994-04-05

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514338, 514422, 514424, 514463, 514468, 544148, 544152, 546197, 546214, 548526, 549298, A61K 31535, A61K 31365, C07D41302

Patent

active

053005007

ABSTRACT:
Novel podophyllotoxin compounds and their use in treating tumors are disclosed. In one embodiment, the compounds have the general formula: ##STR1## wherein NH-R is a selected from the from the group consisting of: ##STR2##

REFERENCES:
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Wang, Z. Q., et al., "Antitumor Agents. 113. New 4.beta.-Arylamino Derivatives of 4'-O-Demethylepipodophyllotoxin and Related Compounds as Potent Inhibitors of Human DNA Topoisomerase II," J. Med. Chem. 33:2660-2666 (1990).

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