4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and us

Details 4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and us 4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and us

1981-03-10

1984-04-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

548343, 548342, 548235, C07D23366, C07D23354, A61K 3140

Patent

active

044434669

ABSTRACT:
The invention provides compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which can be the same or different, are each hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy or nitro; R.sub.4 is hydrogen or alkyl of 1 to 7 carbon atoms; --X-- is ##STR2## R.sub.5 is hydrogen, hydroxy or --OR.sub.6 ; and R.sub.6 is alkyl of 1 to 7 carbon atoms or aryl of 6 to 10 carbon atoms; and their non-toxic pharmaceutically acceptable acid addition salts and mixtures thereof. Processes for the preparation and use of the subject compounds are described, as are novel pharmaceutical compositions comprising at least one of the subject compounds or their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are useful in the treatment of mammals, e.g., as anti-ulcer or anti-hypertensive agents. Furthermore, they are useful as diuretic, sedative, analgesic, anti-inflammatory and tranquilizing agents.

REFERENCES:
patent: 2895959 (1959-07-01), Jeffreys et al.
Novak; J. J. K., Chem. Abs., 84:30780t (1976).
Somin; I. N., Chem. Abs., 71:124547u (1969).

Affiliated with

Also associated with

Rating

4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and us does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and us, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and us will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-95386