4-benzyl-1-(2H)-phthalazinone-derivates

Details 4-benzyl-1-(2H)-phthalazinone-derivates 4-benzyl-1-(2H)-phthalazinone-derivates

1986-11-10

1989-06-20

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

544235, 544237, 514212, 514248, A61K 3150, A61K 3155, C07D40304, C07D40104

Patent

active

048410470

ABSTRACT:
There are provided 4-benzyl-1-(2H)-phthalazinone derivatives having antiallergic activity of the formula ##STR1## wherein R.sub.1 represents fluorine, chlorine, bromine, trifluoromethyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.6 -alkanoyloxy, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, C.sub.2 -C.sub.6 -alkanoylamino, C.sub.2 -C.sub.6 -alkanoyl-C.sub.1 -C.sub.6 -alkylamino or a nitro group, R.sub.2 represents hydrogen or has one of the meanings given for R.sub.1, whereby R.sub.1 and R.sub.2 may be the same or different, the radicals R.sub.3 and R.sub.4 are the same or different and represent hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, benzyloxy or C.sub.2 -C.sub.6 -alkanoyloxy and A represents an azacycloalkanyl radical, the aza nitrogen of which contains a C.sub.1 -C.sub.6 -alkyl group which is substituted by various radicals, and processes for their manufacture.

REFERENCES:
patent: 3017411 (1962-11-01), Engelbrecht
patent: 3813384 (1974-05-01), Volgelsang et al.
Tatsumi et al, "Japan J. Pharmacol.", vol. 30, pp. 37-48 (1980).
Chemical Abstracts, vol. 92 (1980), Item 191057f abstracting Tatsumi et al., above.
Chem. Abstracts, vol. 81, 1974, p. 63654.

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