4-(Benzisothiazol-3-yl)phenoxyacetic acid 1',1'-dioxides as diur

Details 4-(Benzisothiazol-3-yl)phenoxyacetic acid 1',1'-dioxides as diur 4-(Benzisothiazol-3-yl)phenoxyacetic acid 1',1'-dioxides as diur

1982-11-03

1989-09-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548207, A61K 31425, C07D27506

Patent

active

048681881

ABSTRACT:
Novel 4-(benzisothiazol-3-yl)phenoxyacetic acid 1',1'-dioxides of the formula ##STR1## where X is hydrogen, halogen or loweralkyl; R.sub.1 is hydrogen or loweralkyl; R.sub.2 and R.sub.3 are each independently Cl, Br or CH.sub.3, and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretics.

REFERENCES:
patent: 3897476 (1975-07-01), Feit et al.
patent: 4017632 (1977-04-01), Nachmias et al.
patent: 4337261 (1982-06-01), Shutske et al.
patent: 4667041 (1987-05-01), Salzburg
patent: 4728662 (1988-03-01), Shutske
Boshagen et al., "Oxidation products of 3-Amino-1,2-Benzothiazoles . . . ," Chem. Ber. 103:3166-81, (1970).
Beeson et al., Textbook of Medicine, vol. II, 14th Ed., W. B. Saunders, Philadelphia, (1975), pp. 990-991.

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