4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolyti

Details 4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolyti 4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolyti

1990-06-12

1991-06-04

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D40314

Patent

active

050215698

ABSTRACT:
4-Azatricyclo[4.3.1.1(3,8)]undecylarylpiperazine compounds of this invention demonstrated affinity for the 5-hydroxytryptamine-1A receptor site (5-HT.sub.1A) and to a lesser extent, for dopamine-2 receptor sites (D.sub.2). Compounds with such a profile provide a treatment for CNS disorders such as anxiety, depression, and sexual disturbances without EPS liability.

REFERENCES:
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patent: 4797489 (1989-01-01), Abou-Gharbia et al.
patent: 4818756 (1989-04-01), Seidel et al.
patent: 4855430 (1989-08-01), Abou-Gharbia et al.
patent: 4873331 (1989-10-01), Childers, Jr. et al.

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