Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-13
1992-08-11
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548417, 548418, 548419, A61K 3140, C07D20956
Patent
active
051379082
ABSTRACT:
4-Azahexacyclo (5.4.1.0.sup.2,6 .0.sup.3,10 .0.sup.5,9 .0.sup.8,11) dodecane compounds of the formula ##STR1## wherein R, A and B each is hydrogen; a linear or branched alkyl group having one to twelve carbon atoms and optionally including a hydroxyl or halogen substituent; or a phenyl group alone or optionally substituted with a linear or branched alkyl group having one to twelve carbons, which group optionally includes a hydroxyl or halogen substituent; and X is a hydroxyl or --NR.sub.2 group where R is as stated above; or an acid addition salt of such compound. These compounds are useful in pharmaceutical compositions wherein the compound is included in an amount effective to be used as a calcium antogonist, a cardiac agent or an anti-hypertensive agent.
REFERENCES:
Borch, Richard F., Bernstein, Mark D., and Dupont Durst, H., Journal of the American Chemical Society, 1971, Jun. 16, 93(12), 2897-2904.
Sasaki, I Tadashi, Eguchi, Shoji, and Okano, Takashi., Journal of Organic Chemistry, 1981, 46, 4474-4477.
Sasaki, T., Eguchi, S., Kiriyama, T., and Hiroaki, O., Tetrahedron, 1974, 30, 2707-2712.
van der Schyf, Cornelis J., Squier, Gerald J., and Coetzee, William A., Pharmacological Research Communications, 1986, 18(5), 407-417.
Marchand, Alan P., Arney, Benny E. (Jr.), Dave, Paritosh R., and Satyanarayana, N., J. Org. Chem., 1988, 53, 2644-2647.
van der Schyf, Cornelis J., Liebenberg, Wilna., Bornman, Riaan., Dekker, Theodor G., van Rooyen, Petrus H., Fourie, Theunis G., Matthee, Elmare., and Snyckers, Friedrich O., S. Afr. J. Chem., 1989, 42(1), 46-48.
Fourie Theunis G.
Snyckers Friedrich O.
Brust Joseph Paul
Noristan Holdings Limited
LandOfFree
4-azahexacyclododecane compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4-azahexacyclododecane compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-azahexacyclododecane compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-346664