4-azahexacyclododecane compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548417, 548418, 548419, A61K 3140, C07D20956

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active

051379082

ABSTRACT:
4-Azahexacyclo (5.4.1.0.sup.2,6 .0.sup.3,10 .0.sup.5,9 .0.sup.8,11) dodecane compounds of the formula ##STR1## wherein R, A and B each is hydrogen; a linear or branched alkyl group having one to twelve carbon atoms and optionally including a hydroxyl or halogen substituent; or a phenyl group alone or optionally substituted with a linear or branched alkyl group having one to twelve carbons, which group optionally includes a hydroxyl or halogen substituent; and X is a hydroxyl or --NR.sub.2 group where R is as stated above; or an acid addition salt of such compound. These compounds are useful in pharmaceutical compositions wherein the compound is included in an amount effective to be used as a calcium antogonist, a cardiac agent or an anti-hypertensive agent.

REFERENCES:
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Sasaki, I Tadashi, Eguchi, Shoji, and Okano, Takashi., Journal of Organic Chemistry, 1981, 46, 4474-4477.
Sasaki, T., Eguchi, S., Kiriyama, T., and Hiroaki, O., Tetrahedron, 1974, 30, 2707-2712.
van der Schyf, Cornelis J., Squier, Gerald J., and Coetzee, William A., Pharmacological Research Communications, 1986, 18(5), 407-417.
Marchand, Alan P., Arney, Benny E. (Jr.), Dave, Paritosh R., and Satyanarayana, N., J. Org. Chem., 1988, 53, 2644-2647.
van der Schyf, Cornelis J., Liebenberg, Wilna., Bornman, Riaan., Dekker, Theodor G., van Rooyen, Petrus H., Fourie, Theunis G., Matthee, Elmare., and Snyckers, Friedrich O., S. Afr. J. Chem., 1989, 42(1), 46-48.

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