4-Aza-17.beta.-substituted-5.alpha.-androstan-3-one-reductase in

Details 4-Aza-17.beta.-substituted-5.alpha.-androstan-3-one-reductase in 4-Aza-17.beta.-substituted-5.alpha.-androstan-3-one-reductase in

1980-09-23

1983-03-22

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260239BB, 2602393P, 424244, 546 77, 546 78, A61K 31395, A61K 3147, C07D22118

Patent

active

043775845

ABSTRACT:
4-Aza-17.beta.-substituted-5.alpha.-androstan-3-ones and their A-homo analogs of the formula: ##STR1## where Formula (I) may also have the structure of partial Formulas (II) and/or (III);
and pharmaceutically acceptable salts of the above compounds are active as testosterone 5.alpha.-reductase inhibitors, and thus useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.

REFERENCES:
patent: 2227876 (1941-01-01), Bolt
patent: 3239417 (1966-03-01), Di Tullio et al.
patent: 3264301 (1966-08-01), Doorenbos et al.
patent: 3285918 (1966-11-01), Doorenbos et al.
Neri et al., Endo., vol. 91, No. 2, pp. 427-437, (1972).
Doorenbos & Brown, J. Phar. Sci., 60, 8, pp. 1234-1235, (1971).
Doorenbos & Solomons, J. Phar. Sci., 62, 4, pp. 638-640, (1973).
Nayfeh et al., Steroids, 14, pp. 269-283, (1969).

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