Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-08-15
2006-08-15
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S255050, C514S256000, C514S275000, C544S122000, C544S295000, C544S296000, C544S331000
Reexamination Certificate
active
07091202
ABSTRACT:
The invention encompasses compounds of Formula I, which are blockers of KCNQ channels. Blockers of KCNQ channels are known to enchance cognition in laboratory animals. The invention includes, salts, solvates, compositions, and methods of use
REFERENCES:
patent: 4931560 (1990-06-01), Hubele
patent: 5811428 (1998-09-01), Suto et al.
patent: 6281219 (2001-08-01), Cuccia et al.
Gribkoff et al., Effects of Channel Modulators on Cloned Large-Conductance Calcium-Activated Potassium Channels, Molecular Pharmacology, 50(1), pp. 206-217, 1996.
Wang et al., KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel, Science, vol. 282, pp. 1890-1893, 1998.
Robbins, KCNQ potassium channels: physiology, pathophysiology, and pharmacology, Pharmacology & Therapeutics, 90, pp. 1-19, 2001.
Ulrich, Crystallization, Kirk-Othmer Encyclopedia of Chemical Technology, vol. 8, pp. 113-120, (http://www.mrw.interscience.wiley.com/kirk/articles/crysrous.a01/sect4-fs.html) Aug. 2002.
West, Solid Solutions, Solid state chemistry and it's applications, Wiley, New York, pp. 358 and 365, 1988.
Vippagunta et al., Crystalline solids, Advanced Drug Delivery Reviews, 48 (2001), pp. 3-26, 2001.
Bocchino Danielle
Dodd Dharmpal S.
Gillman Kevin W.
Starrett, Jr. John E.
Bristol--Myers Squibb Company
Epperson James
Rao Deepak
LandOfFree
4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3699418