4-Arylpiperidine derivatives

Details 4-Arylpiperidine derivatives 4-Arylpiperidine derivatives

1979-05-01

1981-08-25

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546218, 546217, 424267, C07D21152

Patent

active

042860954

ABSTRACT:
A 4-phenyl piperidine having the formula: ##STR1## wherein R.sub.1 is a straight chain lower alkyl group; R.sub.2 is --COCH.sub.3, --COC.sub.2 H.sub.5 or ##STR2## R.sub.3 is --OCOCH.sub.3, --OCOC.sub.2 H.sub.5, --OCO -cycloalkyl, or --OCOC.sub.6 H.sub.4 --Z; wherein Z is hydrogen, lower alkyl, lower alkoxy or chlorine, and X is oxygen: or an addition salt thereof with a pharmaceutically acceptable organic acid or inorganic acid. The compounds have have found to have, inter alia, stimulatory effects on the central nervous system which is indicative of their use as antidepressants in humans.

REFERENCES:
patent: 3445474 (1969-05-01), Carabateas
patent: 4048314 (1977-09-01), Kubela et al.
R. E. Lyle et al., Jour. Org. Chem., vol. 30(2) (1965), pp. 394-396.
V. Petrow et al., Jour. Pharm. Pharmacol., vol. 14(5) (1962), pp. 306-314.
Schmidle et al., Jour. Am. Chem. Soc., vol. 78, Jan. 20, 1956, pp. 425-428.

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