4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use

Details 4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use 4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use

1992-04-07

1993-02-02

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483661, 5483664, 5483644, A61K 31415, C07D23120

Patent

active

051838257

ABSTRACT:
The compounds of the formula: ##STR1## in which the dotted lines represent optional unsaturation when X is CR.sup.5, Y is CR.sup.6 or X or Y are N; R.sup.1 is hydrogen, alkyl, aryl or arylalkyl; R.sup.2 is hydrogen, alkyl, aryl or arylalkyl; R.sup.3 is alkyl, perfluoromethyl or alkoxy; R.sup.4 is halogen, alkyl or alkoxy; X is CR.sup.5, O, S or N, in which R.sup.5 is hydrogen, halogen, alkyl, or alkoxy; Y is CR.sup.6, O, S or N, in which R.sup.6 is hydrogen, halogen, alkyl or alkoxy; n is one of the integers 0, 1 or 2; m is one of the integers 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof, are useful hypoglycemic agents in the treatment of non-insulin dependent diabetes mellitus.

REFERENCES:
patent: 3190888 (1963-08-01), Wolf et al.
patent: 4081596 (1978-03-01), Moller et al.
Boots et al., Chemical Abstracts, vol. 67 (1967) No. 32651n.
Japan Publication 55-157504 (1980).

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