Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-04-15
1986-06-24
Lesmes, George F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548236, C07D26332, A61K 3142
Patent
active
045968160
ABSTRACT:
Novel oxazole derivatives of the formula ##STR1## (wherein R.sup.1 is hydrogen or a straight, branched or cyclic alkyl group of 1 to 6 carbon atoms, R.sup.2 is hydrogen, halogen, trifluoromethyl, or a straight, branched or cyclic alkylthio of 1 to 3 carbon atoms, and n is 1 or 2) or pharmaceutically acceptable salts or esters thereof are synthesized through several routes. The derivatives have hypoglycemic, glucose tolerance improving and insulin sensitivity increasing activities and are of value as antidiabetic drugs.
REFERENCES:
patent: 3578671 (1971-05-01), Brown
patent: 3579529 (1971-05-01), Brown
Fujita Takeshi
Meguro Kanji
Gibson S. A.
Lesmes George F.
Takeda Chemical Industries Ltd.
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