4-aryl oxazoles

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548236, C07D26332, A61K 3142

Patent

active

045968160

ABSTRACT:
Novel oxazole derivatives of the formula ##STR1## (wherein R.sup.1 is hydrogen or a straight, branched or cyclic alkyl group of 1 to 6 carbon atoms, R.sup.2 is hydrogen, halogen, trifluoromethyl, or a straight, branched or cyclic alkylthio of 1 to 3 carbon atoms, and n is 1 or 2) or pharmaceutically acceptable salts or esters thereof are synthesized through several routes. The derivatives have hypoglycemic, glucose tolerance improving and insulin sensitivity increasing activities and are of value as antidiabetic drugs.

REFERENCES:
patent: 3578671 (1971-05-01), Brown
patent: 3579529 (1971-05-01), Brown

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