4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbino

Details 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbino 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbino

1989-08-28

1991-05-28

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

340596, 340597, 340602, 546112, 546164, 546213, 546212, 546193, 546194, 546232, 546208, 546206, 546205, 546240, 546275, 548517, 548518, 548527, 548574, C07D22307

Patent

active

050196502

ABSTRACT:
Known and novel 4-aryl-4-piperidinecarbinols and heterocyclic analogs are useful as analgesics. Also provided are novel pyrrolidinecarbinols and hexhydroazepine carbinols which are useful as analgesics, antidepressants and, in some cases, as anorectic agents.

REFERENCES:
patent: 3080372 (1963-03-01), Janssen
patent: 3108111 (1963-10-01), Stern et al.
patent: 3317008 (1965-11-01), Kalm et al.
patent: 4072686 (1978-02-01), Adelstein et al.
patent: 4194045 (1980-03-01), Adlestein
patent: 4485109 (1984-11-01), Ciganek
Iorio et al., Tetrahedron, 4983 (1971).
Bergel et al., J. Chem. Soc., 26 (1944).
MacDonald et al., Brit. J. Pharmacol., 1, 4 (1946).
Morrison et al., J. Chem. Soc., 1467 (1950).
Kagi et al., Helv. Chim. Acta, 7, 2489 (1949).
Bondesson et al., Drug Metab. Dispos., 9, 376 (1981).
Bondesson et al., Acta Pharm. Suec., 17, 1 (1980).
Rogers et al., J. Med. Chem., 1980, 23 (6), 688-690, "Some Spiro Analogs of the Potent Analgesic Ketobemidone" (Chem. Abstracts).

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