4-Aryl-4-aryloxypiperidines

Details 4-Aryl-4-aryloxypiperidines 4-Aryl-4-aryloxypiperidines

1980-09-03

1982-04-20

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424258, 424267, 544360, 544408, 546217, 546193, 546157, A61K 31445, C07D21144

Patent

active

043259537

ABSTRACT:
4-Aryl-4-aryloxypiperidines of the general formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R.sup.1 and R.sup.2 are hydrogen or lower alkyl, R.sup.3 is hydrogen, lower alkyl or benzyl, Ar is phenyl optionally substituted by one or more halogen, trifluoromethyl, lower alkyl, lower alkoxy, nitro or amino groups and Ar.sup.1 is a phenyl radical optionally substituted by one or more cyano, methylsulphinyl, methylsulphonyl, lower alkoxy, trifluoromethyl, lower alkyl, lower alkenyl, halogen, nitro, amino or acylamino groups or an aromatic heterocyclic mono- or di-cyclic radical, exhibit activity on the central nervous system, e.g. as antidepressants.

REFERENCES:
patent: 2498435 (1950-02-01), Lee et al.
patent: 4031221 (1977-06-01), Helsley et al.
patent: 4116963 (1978-09-01), Adelstein
Rajsner, et al., "Chemical Abstracts", vol. 59, (1963), 13935-13936d.

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