4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modula

Details 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modula 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modula

1998-10-05

1999-07-13

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514826, A61K 3155

Patent

active

059227354

ABSTRACT:
There is provided novel substituted 4-aryl-3-hydroxyquinolin-2-one derivatives of the formula ##STR1## wherein R is hydrogen or methyl;
R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are independently hydrogen, bromo, chloro or trifluoromethyl, and when R.sup.1, R.sup.3 and R.sup.4 are hydrogen, R.sup.2 is nitro;

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