4-aryl-3-(heteroarylureido)quinoline derivatves

Details 4-aryl-3-(heteroarylureido)quinoline derivatves 4-aryl-3-(heteroarylureido)quinoline derivatves

1993-10-25

1997-01-21

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514259, 514269, 514309, 514312, 514314, 544284, 544298, 544315, 544319, 544322, 544328, 546142, 546153, 546155, 546159, A61K 3147, A61K 31505, C07D40112, C07D40312

Patent

active

055960014

ABSTRACT:
Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and natiatherosclerosis agents.

REFERENCES:
patent: 4623662 (1986-11-01), DeVries
patent: 4716175 (1987-12-01), Hoefle et al.
patent: 4743605 (1988-05-01), Hoefle et al.
patent: 5254565 (1993-10-01), Meguro et al.
Schaefer et al. CA 80: 3361f, p. 294, 1974.

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