4-aryl-3-aminoquinoline-2-one derivatives as potassium channel m

Details 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel m 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel m

1998-08-24

1999-10-26

Mach, D M

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514313, 546157, C07D21516, A01N 4342

Patent

active

059729619

ABSTRACT:
The present invention provides novel 4-aryl-3-aminoquinolin-2-one derivatives having the general formula ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulators of the large conductance calcium-activated K.sup.+ channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.

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