4-Aroylimidazol-2-ones and their use as pharmaceuticals

Details 4-Aroylimidazol-2-ones and their use as pharmaceuticals 4-Aroylimidazol-2-ones and their use as pharmaceuticals

1982-09-13

1983-09-20

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

42424854, 424250, 424267, 544139, 544370, 546210, 548317, 548318, 548321, A61K 31415, C07D23370

Patent

active

044056354

ABSTRACT:
Novel 4-aroylimidazol-2-ones of the following general structure which are useful as antihypertensives, cardiotonics, antithrombotics, bronchodilators and uterospasmolytics ##STR1## wherein Ar is 2-furyl, 2-thienyl or phenyl, the latter of which may optionally be substituted with one or two X groups; X is halogen, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, methylenedioxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulfoxide, C.sub.1-4 alkylsulfone, CF.sub.3, --SO.sub.2 N(R.sub.2).sub.2, NR.sub.3 R.sub.4, pyrrolidino, piperidino, morpholino, piperazino or N'-alkyl-piperazino, R is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkylcarbonyl or benzyl; each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or C.sub.1-4 alkyl; and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 2441933 (1948-05-01), Duschinsky
patent: 2514380 (1950-07-01), Duschinsky
Duschinsky and Dolan "J. Am. Chem. Soc." vol. 68, pp. 2350-2355 (1946); ibid. vol. 70, pp. 657-662 (1948); ibid. vol. 67 pp. 2079-2084 (1945).
Rozin et al. "Khim. Geterotsikl. Soedin." vol. 4, No. 4, pp. 698-701 (1968).
Dage et al. "Fed. Proc." vol. 39, p. 1105 (1980).
Hsieh et al. "Fed. Proc." vol. 39, p. 1106 (1980).

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