4-anilino-3-quinolinecarbonitriles for the treatment of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S157000, C546S153000, C514S313000, C514S253060

Reexamination Certificate

active

07417148

ABSTRACT:
Compounds of the formula:wherein:n is an integer from 1-3;X is N, CH, provided that when X is N, n is 2 or 3;R is alkyl of 1 to 3 carbon atoms;R1is 2,4-diCl, 5-OMe; 2,4-diCl; 3,4,5-tri-OMe; 2-Cl, 5-OMe; 2-Me, 5-OMe; 2,4-di-Me; 2,4-diMe-5-OMe, 2,4-diCl, 5-OEt;R2is alkyl of 1 to 2 carbon atoms, and pharmaceutically acceptable salts thereof.

REFERENCES:
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patent: 6780996 (2004-08-01), Boschelli et al.
patent: WO 03/093241 (2003-11-01), None
patent: WO 2004/075898 (2004-09-01), None
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Berger, D., et al.; Substituted 4-Anilino-7-phenyl-3-quinolinecarbonitriles as Src Kinase Inhibitors; Bioorg. Med. Chem. Lett. 12:2989-2992 (2002).
Boschelli, D.H.; et al.; J. Med. Chem. 44:3965-3911 (2001).
Boschelli, D.H.; et al.; J. Med. Chem. 47:1599-1601 (2004).
Boschelli, D.H., et al.; J. Med. Chem. 44:822-833 (2001).
Boschelli, D.H., et al.; Bioorganic & Medicinal Chemistry Letters 13:3797-3800 (2003).
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Ye, F.; 221stNational Meeting of the American Chemical Society, San Diego (Apr. 2001).
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