Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-06-29
2008-09-09
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S209000
Reexamination Certificate
active
07423053
ABSTRACT:
Novel 4-aminothiazole derivatives are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminothiazole derivatives.
REFERENCES:
patent: 6262096 (2001-07-01), Kim et al.
patent: 6569878 (2003-05-01), Chong et al.
patent: 7211576 (2007-05-01), Ding et al.
patent: 2003/0220326 (2003-11-01), Chong et al.
patent: WO 99/21845 (1999-05-01), None
patent: WO 01/19825 (2001-03-01), None
patent: WO 01/38315 (2001-05-01), None
patent: WO 01/56567 (2001-08-01), None
patent: WO 01/79198 (2001-10-01), None
patent: WO 03/011843 (2003-02-01), None
De Azevedo et al., Eur. J. Biochem., 243, pp. 518-526 (1997).
Sielecki et al., J. Med. Chem., 43, pp. 1-18 (2000).
Harrington et al., Proc. Natl. Acad. Sci. USA, 95, pp. 11945-11950 (1998).
Garrett et al., Current Opin. Genetics Develop., 9, pp. 104-111 (1999).
Hoessel et al., Nature Cell Biology, 1, pp. 60-67 (1999).
Sielecki et al., Bioorg. Med. Chem. Lett., 11, pp. 1157-1160 (2001).
Nugiel et al., J. Med. Chem., 44, pp. 1334-1336 (2001).
Fry et al., J. Biol. Chem., 276, pp. 16617-16623 (2001).
Soni et al., Biochem. Biophys. Res. Commun., 275, pp. 877-884 (2000).
Jeong et al., Bioorg. Med. Chem. Lett., 10, pp. 1819-1822 (2000).
Ryu et al., Bioorg. Med. Chem. Lett., 10, pp. 461-464 (2000).
Reinhold et al., J. Biol. Chem., 273, pp. 3803-3807 1998).
Toogood et al., J. Med. Chem., 43, pp. 4606-4616 (2000).
Wilkinson et al., Emerging Drugs, 5, pp. 287-297 (2000).
Dumas, J., Exp. Opin. Ther. Patents, 11, pp. 405-429 (2001).
Fischer, P. M., Curr. Opin. in Drug Discov. and Develop., 4, pp. 623-634 (2001).
Meijer et al., Eur. J. Biochem., 267, pp. 5983-5994 (2000).
Honma et al., 221stNational ACS Meeting., Medi. 136 (2001).
Carlson et al., Cancer Res., 56, pp. 2973-2978 (1996).
Kakeya et al., Cancer Res., 58, pp. 704-710 (1998).
Mgbonyebi et al., Cancer Res., 59, pp. 1903-1910 (1999).
Zaharevitz et al., Cancer Res., 59, pp. 2566-2569 (1999).
Harper, J. W., Cancer Surveys, 29, pp. 91-107 (1997).
Chen Li
Chu Xin-Jie
Lovey Allen John
Zhao Chunlin
Hoffmann-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
Saeed Kamal A
Yao Gene J.
LandOfFree
4-Aminothiazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4-Aminothiazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-Aminothiazole derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3985818