Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1997-08-05
1999-12-07
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
544333, 546270, 548202, 548235, 548241, 548243, 548248, 5482672, 5483117, 5483644, 548518, 549 9, 549 27, 549 60, 549346, 549390, 549472, C07D26120, C07D27503, C07D27702, C07D30702, C07D31178, C07D31320, C07D33700, C07D40914
Patent
active
059986131
ABSTRACT:
The present invention relates to novel 4-aminotetrahydrobenzisoxazoles or 4-aminotetrahydrobenziothiazoles having gamma-aminobutanoic acid (GABA)-uptake inhibiting activity and thus useful in the treatment of analgesia, psychosis, convulsions, anxiety, epileptic disorders or muscular and movement disorders, such as spastic disorders or symptoms in Huntington's disease or Parkinson disease.
REFERENCES:
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patent: 4452799 (1984-06-01), Temple, Jr. et al.
patent: 4514414 (1985-04-01), Rondinell et al.
patent: 5143923 (1992-09-01), Hrib et al.
patent: 5225412 (1993-07-01), Hrib et al.
Birgitte Sokilde, Neurotransmitter Defekter I Alzheimers Syge (Design, syntese og biologisk test af heterocykliske muscarine, nicotine og GABA erge receptorligander), Danmarks Farmaceutiske Hojskole, Institut for Organisk Kemi, Kobenhavn (Ph.D. Thesis-Date of Publication Unknown).
Eur.J.Pharmacol., vol. 236, (1993), H.S. White et al. "Anticonvulsant Activity of the Gamma-Aminobutyric Acid Uptake Inhibitor N-4, 4-disphenyl-3-butenyl- 4,5,6,7,-tetrahydrioxazolo (4,5-c) pyridin-3-ol" pp. 147-149.
J.Med Chem., vol. 28, 1985, F.E. Ali et al., "Orally Active and Potent Inhibitors of Gamma-Aminobutyric Acid Uptake", pp. 653-660.
Falch Erik
Frolund Bente
Krogsgaard-Larsen Povl
Moltzen Lenz Sibylle
Perregaard Jens Kristian
H. Lundbeck A/S
Richter Johann
Solola Taofiq A.
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