Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Patent
1993-11-19
1995-08-08
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
514212, 514218, 514241, 514259, 544180, 544384, 544293, 540575, 540600, A61K 31505, C07D23995
Patent
active
054398959
ABSTRACT:
The compounds of the formula: ##STR1## wherein R.sup.1, Y, A, Z, CyB, R.sup.3, R.sup.4, n and m are described in the specification and claims.
and acid addition salts thereof, salts thereof, and hydrates thereof; have inhibitory effect on cGMP-PDE, and additionally on TXA.sub.2 synthetase.
REFERENCES:
patent: 3753981 (1973-08-01), Breuer et al.
patent: 3772295 (1973-11-01), Robba et al.
patent: 3819628 (1974-06-01), Simpson
patent: 3971783 (1976-07-01), Barnish et al.
patent: 4060615 (1977-11-01), Matier et al.
patent: 4269834 (1981-05-01), Nauta
patent: 4306065 (1981-12-01), Chen
patent: 5047404 (1991-09-01), Coates et al.
Kondo Kigen
Konishi Yoshitaka
Lee Sung J.
Macina Orest T.
Yu Dingwei T.
Grumbling Matthew V.
Ono Pharmaceutical Co. Ltd.
Shah Mukund J.
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