4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors

Details 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors

1995-05-23

1997-06-17

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514258, 514260, 514259, A61K 31505, A61K 3152

Patent

active

056397577

ABSTRACT:
Certain 4-aminopyrrolo[2,3-d]pyrimidine compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and are useful for immunoregulation and for the treatment of cancer, angiogenesis and atherosclerosis.

REFERENCES:
patent: 5036071 (1991-07-01), Johansson et al.
patent: 5457105 (1995-10-01), Barker
patent: 5475001 (1995-12-01), Barker
Chemical Abstracts 111:39290e, "Synthesis and Biological Activity of Pyrrolo [2,3-d] Pyrimidines", Dave et al. Aug. 1988.
Chaitanya, G. Dave. Indian Journal of Chemistry vol. 27B, Aug. 1988, pp. 778-780, "Synthesis & Biological Activity of Pyrrolo[2,3-d]pyrimidinest".
Chaitanya, G. Dave. Indian Journal of Chemistry 64, 713 (1987) pp. 713-715, "Pyrrolo[2,3-d]pyrimidines. Synthesis and Reaction of 2-Amino-3-cyanopyrroles".

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