4-aminopyrimidine-5-one derivatives

Details 4-aminopyrimidine-5-one derivatives 4-aminopyrimidine-5-one derivatives

2006-06-20

2009-11-10

Rao, Deepak (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S325000, C544S329000, C544S334000

Reexamination Certificate

active

07615634

ABSTRACT:
Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

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