Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-01-02
2007-01-02
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252180, C514S275000, C544S122000, C544S295000, C544S323000, C544S324000, C544S325000
Reexamination Certificate
active
10770379
ABSTRACT:
Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminopyrimidine-5-one derivatives.
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Abstract corresponding to WO 05/037800 (B2), 2005.
Bartkovitz David Joseph
Chu Xin-Jie
Ding Qingjie
Jiang Nan
Lovey Allen John
Hoffmann-La Roche Inc.
Johnston George W.
Rao Deepak
Rocha-Tramaloni Patricia S.
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