4-Aminomethyldibenzobicyclo[5.1.0]octanes

Details 4-Aminomethyldibenzobicyclo[5.1.0]octanes 4-Aminomethyldibenzobicyclo[5.1.0]octanes

1976-10-01

1978-04-04

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603437, 260465R, 2605011, 260562P, 260649R, 424280, 424316, 424330, C07C 8728

Patent

active

040828018

ABSTRACT:
The new 4-aminomethyldibenzobicyclo[5.1.0]octane compounds of the present invention are prepared from the corresponding 4-halo compounds by reaction with a metal cyanide to produce the corresponding 4-cyano compound, which is reduced with an alkali metal aluminum hydride to produce the desired 4-aminomethyl compound. These new aminomethyldibenzobicyclo[5.1.0]octane compounds are converted to the corresponding secondary and tertiary amino derivatives.
These new compounds are useful as antiarrhythmic agents and can be used to overcome cardiac irregularities.

REFERENCES:
patent: 3480624 (1969-11-01), Fouche
patent: 3489799 (1970-01-01), Schmidt et al.
patent: 3574199 (1971-04-01), Coyne et al.
patent: 3723420 (1973-03-01), Dvolaitzky et al.

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