Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-04-17
2007-04-17
Wilson, James O. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S197000, C546S205000, C546S207000, C546S214000
Reexamination Certificate
active
10353307
ABSTRACT:
The present invention of compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, —R1—R2— is a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl or hydroxy; R3is hydrogen or halo; R4is hydrogen or C1-6alkyl; R5is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, oxoC5-6cycloalkyl, C2-6alkenyl, or L is a radical of formula -Alk-R6—, Alk-X—R7, -Alk-Y—C(═O)—R9, or -Alk-Y—C(═O)—NR11R12wherein each Alk is C1-12alkanediyl; and R6is hydrogen, amino, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, oxoC5-6cycloalkyl, aryl or a heterocyclic ringsystem; R7is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, aryl or a heterocyclic ringsystem; X is O, S, SO2or NR8; said R8being hydrogen or C1-6alkyl; R9is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy, hydroxy or aryl; Y is a direct bond or NR10; said R10being hydrogen, or C1-6alkyl; R11and R12each independently are hydrogen, C1-6alkyl, C3-6cycloalkyl, or R11and R12combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating or preventing gastrointestinal disorders.
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Bosmans Jean-Paul Rene Marie Andre
De Cleyn Michel Anna Jozef
Gijsen Henricus Jacobus Maria
Meulemans Ann Louise Gabriëlle
Janssen Pharmaceutica N.V.
Ward Paul V
Wilson James O.
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