4-aminomethyl-1-azaadamantane derived benzamides

Details 4-aminomethyl-1-azaadamantane derived benzamides 4-aminomethyl-1-azaadamantane derived benzamides

1992-07-27

1998-11-24

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 72, 546 94, 546 98, 546100, 546133, 514183, 514294, 514296, A61K 3144, C07D45100, C07D22102

Patent

active

058409033

ABSTRACT:
This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein Z is selected from the group consisting of ##STR2## R.sub.1 is alkoxy of one to six carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group consisting of hydrogen, halogen, CF.sub.3, hydroxy, alkoxy of one to six carbon atoms, acyl of two to seven carbon atoms, amino, amino substituted by one or two alkyl groups of one to six carbon atoms, C.sub.2 -C.sub.7 acylamino, aminocarbonyl, aminosulfone optionally substituted by one or two alkyl groups of one to six carbon atoms, C.sub.1 -C.sub.6 alkylsulfone and nitro;

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patent: 4950759 (1990-08-01), Wijngaarden et al.
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patent: 5001133 (1991-03-01), Richardson et al.
patent: 5140023 (1992-08-01), Becker et al.
Sandoz AG New N-oxide(s) of alkylene bridged piperidinol etc. Derwent Abstract 89/179167/25 B0025,26 Jun. 1989.

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