4-Aminocarbonylaminomethyl-1-benzylpyrrolidin-2-ones as nootropi

Details 4-Aminocarbonylaminomethyl-1-benzylpyrrolidin-2-ones as nootropi 4-Aminocarbonylaminomethyl-1-benzylpyrrolidin-2-ones as nootropi

1985-05-24

1987-06-02

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514214, 514234, 514252, 514326, 514343, 540585, 544131, 544141, 544372, 546193, 546208, 546281, 548518, 548550, A61K 3140, C07D20712

Patent

active

046704566

ABSTRACT:
The invention relates to new substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;

REFERENCES:
patent: 3459738 (1969-08-01), Morren
patent: 4369139 (1983-01-01), Kyburz et al.
U.S. Ser. No. 657,219, Weber et al., filed 10-3-1984; and U.S. Ser. No. 678,739, filed 7-9-1984.
B. R. J. Nicholaus, Drug. Dev. Res. 2, 463-474 (1982).
R. Cumin et al, Psychopharmacology, 78, 104-111 (1982).
T. M. Itil et al, Psychopharmacology Bulletib, 19/4, 708-716 (1983).
B. P. H. Poschel et al, Psychopha-macology Bulletin, 19/4, 720-721 (1983).
T. A. Pugsley et al, Psychopharmacology Bulletin, 19/4, 721-726 (1983).
R. J. Branconnier et al, Psychopharmacology Bulletin, 19/4, 726-730 (1983).
Stratford et al, J. Med. Chem., 26 pp. 1463-1469 (1983).

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