4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines

Details 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines

1999-09-07

2000-10-31

Seaman, D. Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546159, A61K 3147, C07D21538

Patent

active

061403431

ABSTRACT:
Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

REFERENCES:
patent: 5231101 (1993-07-01), Honda et al.
patent: 5231102 (1993-07-01), Baker et al.
patent: 5288725 (1994-02-01), Witherup et al.
Gordon DJ, et al., Circulation. 79(1):8-15, Jan. 1989, "High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies".
Chemical Abstracts vol. 116, 1992, 116:151569g.
Chemical Abstracts vol. 123, 1995, 123:55716b.

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