4-Amino-substituted 1,2-dihydroxynaphthalene derivatives useful

Details 4-Amino-substituted 1,2-dihydroxynaphthalene derivatives useful 4-Amino-substituted 1,2-dihydroxynaphthalene derivatives useful

1987-07-10

1989-11-21

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514617, 514619, 514629, 514630, 514648, 514657, 514 581, 514173, 514174, 514399, 546144, 546164, 546165, 546206, 548491, 548509, 548954, A61K 31445

Patent

active

048823392

ABSTRACT:
Disclosed are compounds of the formula ##STR1## wherein R.sub.1 represents unsubstituted or lower alkyl-substituted C.sub.3 -C.sub.7 -cycloalkyl, unsubstituted or lower alkyl substituted C.sub.7 -or C.sub.8 -bicycloalkyl, unsubstituted or lower alkyl-substituted adamantyl, 4-piperidinyl or N-lower alkyl or aryl-lower alkyl-substituted piperidinyl, 1- or 2-indanyl, 1- or 2-tetrahydronaphthyl, 1- or 2-perhydroindanyl, 1- or 2-perhydronaphthyl; R.sub.2 represents hydrogen, lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, aryl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, lower alkanoyl or aryl-lower alkanoyl; or R.sub.1 and R.sub.2 combined with the nitrogen to which they are attached represent pyrrolidino, piperidino, perhydroazepino, morpholino, thiomorpholino, tetrahydro- or perhydro-(isoquinolinyl or quinolinyl), dihydro- or perhydroindolyl, piperazino or N-lower alkyl-piperazino; R.sub.3 represents hydrogen, lower alkyl, halogen or lower alkoxy; pharmaceutically acceptable ester and ether derivatives thereof; and pharmaceutically acceptable acid-addition salts of any said basic compounds of formula I and derivatives thereof; as 5-lipoxygenase inhibitors.

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