4-amino quinolines and naphthyridines and their use as medicines

Details 4-amino quinolines and naphthyridines and their use as medicines 4-amino quinolines and naphthyridines and their use as medicines

1989-06-06

1991-06-25

Dentz, Bernard I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, 514210, 5142345, 514258, 514291, 514293, 514313, 540481, 540597, 544127, 544362, 546 83, 546 90, 546122, 546123, 546162, A61K 31435, A61K 3147, C07D21554, C07D47104

Patent

active

050267116

ABSTRACT:
Compounds represented by the general formula: ##STR1## in which R.sub.1 and R.sub.2 are selected from hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl , phenyl or benzyl or R.sub.1 and R.sub.2 form together with the nitrogen atom to which they are attached a C.sub.4 -C.sub.8 saturated heterocycle, R.sub.3 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl or C.sub.7 -C.sub.9 phenyl-alkyl, R.sub.4 is selected from hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.5 and R.sub.6 are selected from hydrogen or halogen, C.sub.1 -C.sub.3 or alkoxy, nitro or trifluoromethyl; Z is selected from OH, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.4 alkyl, benzyl, C.sub.4 -C.sub.6 aryl with or without a heteroatom, or NR.sub.8 R.sub.9, R.sub.8 and R.sub.9 being selected from hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or benzyl; R.sub.10 is selected from hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl; n is 0, 1 or 3, p is 0 or 1 and one of the symbols A, B, C, D represents N and the others CH or A, B, C, D all represent CH and their acid addition salts, and their salts with bases. The compounds are useful in the prevention and treatment of cardiovascular diseases, as anti-allergic drugs, in the prevention and treatment of infectious states, and for the treatment of anxiety.

REFERENCES:
Wastek et al., Eur. J. of Pharmacology, vol. 50, pp. 445-447, (1978).
Cyrus J. Ohnmacht et al., "Antimalarials. 5. .alpha.-Dibutylaminomethyl- and .alpha.-(2-Piperidyl)-3-Quinolinemethanols" Journal of Medicinal Chemistry, 1971, vol. 14, No. 1, pp. 17-24.
"Heterocyclic Compounds (More Than One Hetero Atom)", Chemical Abstracts, vol. 97, No. 19, Nov. 8, 1982.

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