Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-10-27
1997-11-25
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546224, A61K 31445, C07D21156
Patent
active
056913583
ABSTRACT:
Piperidinyl substituted benzamides of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R.sup.1 is hydrogen or halo; R.sup.2 is halo; R.sup.3 is hydrogen or halo; R.sup.4 and R.sup.5 each independently are hydrogen, C.sub.1-4 alkyl or haloC.sub.1-4 alkyl; and the group NR.sup.4 R.sup.5 may also be azido, Alk is C.sub.2-4 alkanediyl; pharmaceutical compositions containing said compounds of formula (I) as active ingredient; use of said compounds as a medicine; process of preparing said compounds; compounds of formula (I) containing a radioactive isotope; process of marking 5HT.sub.2 -receptor sites; and process for imaging an organ are disclosed.
REFERENCES:
Appel et al. "Autoradiographic characterization of 1-(2,5-dimethoxy-4-iodo(125)phenyl)-2-aminopropane binding to 5HT2 and 5HTic receptors in rat brain." J. Pharm. Exp. Ther., 1990.
Leysen Josepha Eduarda Maria Francisca
Van Daele Georges Henri Paul
Chang Ceila
Janssen Pharmaceutica N.V.
Metz Charles J.
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