4-amino-.DELTA..sup.4 -steroids and their use as 5.alpha.-reduct

Details 4-amino-.DELTA..sup.4 -steroids and their use as 5.alpha.-reduct 4-amino-.DELTA..sup.4 -steroids and their use as 5.alpha.-reduct

1992-03-20

1993-06-08

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

552515, C07J 2100, C07J 4100

Patent

active

052181103

ABSTRACT:
The present invention relates to 4-azido-.DELTA..sup.4 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating.

REFERENCES:
patent: 3637668 (1972-01-01), Laurent et al.
patent: 3780070 (1973-12-01), Shapiro
Ekhato et al., J. Chem. Soc. Perkin Trans. I, 1988, 3239.
Chemical Abstracts, 64, 2142e (1966).
Derwent Basic Abstract 9186 (JP 17673/63).
Derwent Basic Abstract 11,765 (JP 4476/64).
R. D. Lynch, "Synthesis and Chemistry of Steroidal Azido Ketones. Possible Photoaffinity Labels of Steroids Receptor Proteins," Ph.D. Dissertation (Vanderbilt University), Dec. 1977, pp. XIV, XV, 22, 26, 40, 41, 42, 95 and 96.
Mushfiq, M., Chemical Abstracts, vol. 106, No. 21, dated May 25, 1987. Abstract No. 176736.

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