4-amino-.DELTA..sup.4,6 -steroids and their use as 5.alpha.-redu

Details 4-amino-.DELTA..sup.4,6 -steroids and their use as 5.alpha.-redu 4-amino-.DELTA..sup.4,6 -steroids and their use as 5.alpha.-redu

1992-03-20

1993-02-23

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 540 28, 552515, C07J 2100, C07J 4100, A61K 3158

Patent

active

051890321

ABSTRACT:
The present invention relates to 4-amino-.DELTA..sup.4,6 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4,5-epoxy steroid with sodium azide in an inert solvent in the presence of a strong acid such as sulfuric acid at about 100.degree. C.

REFERENCES:
patent: 3637668 (1972-01-01), Laurent et al.
Ekhato et al., J. Chem. Soc. Perkin Trans. I, 1988, 3239.
Chemical Abstracts, 64, 2142e (1966).
Derwent Basic Abstract 9186 (JP 17673/63).
Derwent Basic Abstract 11,765 (JP 4476/64).
R. D. Lynch, "Synthesis and Chemistry of Steroidal Azido Ketones. Possible Photoaffinity Labels of Steroids Receptor Proteins," Ph.D. Dissertation (Vanderbilt University), Dec. 1977, pp. XIV, XV, 22, 26, 40, 41, 42, 95 and 96.

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