4-amino-.DELTA.4-steroids and their use as 5.alpha.-reductase in

Details 4-amino-.DELTA.4-steroids and their use as 5.alpha.-reductase in 4-amino-.DELTA.4-steroids and their use as 5.alpha.-reductase in

1992-12-20

1994-06-07

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514173, 514176, 514178, 514179, 514181, A61K 3157, A61K 31575, A61K 3158

Patent

active

053189612

ABSTRACT:
The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are inhibitors of 5.alpha.-reductase. The compounds are useful for treating DHT-mediated diseases.

REFERENCES:
patent: 3637668 (1972-01-01), Laurent et al.
patent: 3780070 (1973-12-01), Shapiro
patent: 4757061 (1988-07-01), Faustini et al.
patent: 5189032 (1993-02-01), Weintraub
Ekhato et al., J. Chem. Soc. Perkin Trans. I, 1988, 3239.
Chemical Abstracts, 64, 2142e (1966).
Derwent Basic Abstract 9186 (JP 17673/63).
Derwent Basic Abstract 11,765 (JP 4476/64).
R. D. Lynch, "Synthesis and Chemistry of Steroidal Azido Ketones. Possible Photoaffinity Labels of Steroids Receptor Proteins," Ph.D. Dissertation (Vanderbilt University), Dec. 1977, pp. XIV,XV, 22,26,40,41,42,95, and 96.

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