4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardi

Details 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardi 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardi

1980-04-28

1981-12-15

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544238, 546314, 546315, C07D40104, A61K 3150

Patent

active

043059430

ABSTRACT:
4-Amino-2-R-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as cardiotonics, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents are prepared by: (a) reaction of 2-R-6-PY-3(2H)-pyridazinone (II) with hydrazine; (b) conversion from 2,3-dihydro-2-R-3-oxo-6-PY-4-pyridazinecarboxamide (III); or, (c) conversion form 2,3-dihydro-2-R-3-oxo-6-PY-4-pyridazinecarboxylic acid hydrazide (IV). Also shown are: the use of I or salts as cardiotonic agents; and, the preparation of intermediates.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-07-01), Lesher et al.
patent: 4107315 (1978-08-01), Lesher et al.
patent: 4137233 (1979-01-01), Lesher et al.
patent: 4199586 (1980-04-01), Lesher et al.
Takaya et al., Chem Abs. 90, 80709j.

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